Statistical challenges in nanoscale biophysics

Nanoscale Semiconductor Devices as New Biomaterials.

Research on nanoscale semiconductor devices will elicit a novel understanding of biological systems. First, we discuss why it is necessary to build interfaces between cells and semiconductor nanoelectronics. Second, we describe some recent molecular biophysics studies with nanowire field effect transistor sensors. Third, we present the use of nanowire transistors as electrical recording devices...

Challenges and opportunities for structural DNA nanotechnology.

DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical...

Statistical Physics of Biocomplexity

Biology and physics share common ancestors. The progress of methods of statistical physics and the developments of new physical tools and various ingenious experimental techniques have triggered dramatic progress for the field of biophysics. Likewise, the two fields fertilized each other repeatedly over the last decades. Most import antly, the complexity of biophysics inspired new developments ...

Stochastic Networks in Nanoscale Biophysics: Modeling Enzymatic Reaction of a Single Protein

Advances in nanotechnology enable scientists for the first time to study biological processes on a nanoscale molecule-by-molecule basis. A surprising discovery from recent nanoscale single-molecule biophysics experiments is that biological reactions involving enzymes behave fundamentally differently from what classical theory predicts. In this article we introduce a stochastic network model to ...

Single-molecule biophysics: untying a nanoscale knot.